The Senckenberg Gesellschaft für Naturforschung has a federal structure with ten Locations in seven of the German states: Hesse, Thuringia, Saxony, Brandenburg, Lower Saxony, Baden-Württemberg and Hamburg. The headquerters are located inFrankfurt am Main where Senckenberg was founded in 1817.
In 1928 the marine branch in Wilhelmshaven was founded. In 1969 the "Lochmühle" research station was established, serving phycology and environmental research. Due to the growth of this station it soon had to be moved to a larger, more modern building, now in Gelnhausen. In 1983 the Messel Research station came into existence. In 2000 the German Centre for Marine Biodiversity Research (DZMB) was founded with locations at Wilhelmshaven and Hamburg. In the same year the Institute for Quaternary Paleontology (now Research Station for Quaternary Paleontology) in Weimar joined Senckenberg. The largest expansion was the fusion of the former Saxon State Museums in Dresden and Görlitz as well as the German Entomological Institut in Müncheberg with Senckenberg on January 1, 2009.